A high risk “twin/vanishing twin/triploidy” result means that the Panorama algorithm detected an extra DNA pattern in the sample.  This could mean a few different things: the pregnancy may be a twin pregnancy that you didn’t know about yet, the pregnancy may have started as a twin pregnancy but one of the twins didn’t survive (also called vanishing twin) and rarely,  the pregnancy could be affected with a condition called triploidy where there is a whole extra set of chromosomes present. 

It is highly recommended to have a dating ultrasound prior to having the Panorama, not only for dating the pregnancy, but also to determine if there may be ongoing twins or possibility of a vanishing twin. In vanishing twin pregnancies, NIPT is not recommended. Alternate screening such as maternal serum testing or nuchal translucency ultrasound would be more appropriate. If there is a vanishing twin pregnancy, Panorama will not be able to provide a result and there will not be a refund option as this result could have clinical implications.