	Fixed Panels (Fx Panels)	Expanded Panel (Ex Panel)	Progressive Panels (ProGx Panels)
Price	Starting at $1,450 CAD (Sequencing) Starting at $1,950 CAD (Seq+CNV)	$1,350 CAD (Sequencing) $1,900 CAD (Seq+CNV)	$3,850 CAD (Seq+CNV) +$1,000 (Reflex to WGS)
Description	Classic NGS panels with phenotype-specific, curated gene content	Similar to a clinical exome, with optimized analyses for known conditions	Custom panels run off WGS, enabling greater reflexing and del/dup analyses
Coverage	>98% of targeted bases covered >20x	~95% of target bases covered >20x	~99-100% of targeted bases covered >10x
Read Depth	150x	80-100x	30x
Genomic Regions	Exons, 10bp E/I boundary	Exons, 10bp E/I boundary	Exons, Introns Intergenic UTRs
Del/Dup	Available as add-on	Available as add-on	Included
Repeat Expansion	Included, when applicable	Available as add-on	Available as add-on
Raw Data	Not Available	Available	Available after reflex
Reflex	Not Available	N/A	Additional Charge
	Patient Package – Fixed Panels Increased coverage of all genes on the selected panel Curated panels with focused gene content means less likehood of a VUS All sequencing includes repeat expansion, when applicable	Patient Package – Expanded Panel Largest panel available (>6,700 genes) All >6,700 genes are always sequenced 1 step process, meaning no additional step of reflexing to larger data set Raw data available, upon request	Package-Progressive-Panels Run on the backbone of WGS Best way to call CNVs and structural variants Includes mitochondrial analyses Reflex to WGS available

WHO IS THIS TEST FOR?

LifeLabs Genetics offers testing for >200 panel options.

Fixed Panels are best suited for healthcare providers who:

Seek confirmatory diagnostic testing for patients with suspected phenotypes
Prefer to minimize the likelihood of identifying variants of uncertain significance
Would like to test only those genes most commonly associated with the suspected phenotype

The Expanded Panel is best suited for healthcare providers who:

Aim to gain deeper insights into clinically relevant genes
Have a patient with an unidentified and/or highly heterogeneous phenotype
Do not have access to whole exome sequencing
Have a patient with an identified phenotype and are in search of an affordable clinically-based exome instead of a disease-specific panel

Progressive panels are best suited for healthcare providers who:

Have a patient with an unidentified or heterogeneous phenotype, where whole exome sequencing has already been attempted or was not available
Have a patient with an identified phenotype, but prefer to test a large number of genes related to the specified clinical indications
Would like to expand on the fixed content panels currently offered through LifeLabs Genetics or any other provider of genetic testing
Would like the ability to reflex to a larger data set if their choice in panel comes back negative

These tests do not identify your ancestry.

How to Order

TIMING

Babies, children, and adults can all benefit from genetic testing depending on the health issues or life events they are facing
Turnaround times vary by test; results may become available to your physician in 4 to 6 weeks; expedited testing for prenatal cases is also available
Timing estimates do not include time required for physician appointments, requisitions, consent signatures, sample collection, statutory holidays, or courier/shipping times (samples are analyzed in Toronto or Germany)

How to Order

TEST SPECIFICS

Panel testing utilizes next-generation sequencing to achieve optimal coverage of targeted bases
Fx Panels have 96.1% technical sensitivity (increases to 99.1% with Sanger fill-in)
Ex Panel has 94.1% technical sensitivity (increased sensitivity depending on clinical indications for testing)
ProGx Panels have 99.1% technical sensitivity (higher sensitivity as these panels are run off a WGS backbone)
Simplified Pricing Structure – Most panels are $1,950 CAD, including deletion/duplication

How to Order

RESULTS & REPORTS

Reports are sent to physicians only; LifeLabs Genetics cannot share results directly with patients. The ordering physician will receive an email or fax when results become available. Actual results are never shared via email.

Results documentation includes the following:

Test type, date, methodology, result, and interpretation
Positive result: Indicates a genetic variant was identified in a specific gene and that variant is pathogenic of likely pathogenic (highly likely to be causal of the disease-related condition).
Uncertain result: Sometimes, gene variants are proven but their significance is not clear. This is stated in the results and discussed with you by your physician. This category of variant is not reported for fetal samples or samples from deceased persons.
Negative result: If no disease-causing variant is found, genetic changes responsible for the disease or a tendency to have a disease may still exist and cannot usually be fully excluded.

Expanded Carrier Screening

Non-Invasive Prenatal Testing

TreatGxPlus

Genetic Testing For Breast Cancer

Known Mutations and Single Genes