Multi-Gene Panel Testing

LifeLabs Genetics offers testing for >200 panel options.

Fixed Panels are best suited for healthcare providers who:

• Seek confirmatory diagnostic testing for patients with suspected phenotypes
• Prefer to minimize the likelihood of identifying variants of uncertain significance
• Would like to test only those genes most commonly associated with the suspected phenotype

The Expanded Panel is best suited for healthcare providers who:

• Aim to gain deeper insights into clinically relevant genes
• Have a patient with an unidentified and/or highly heterogeneous phenotype
• Do not have access to whole exome sequencing
• Have a patient with an identified phenotype and are in search of an affordable clinically-based exome instead of a disease-specific panel

Progressive panels are best suited for healthcare providers who:

• Have a patient with an unidentified or heterogeneous phenotype, where whole exome sequencing has already been attempted or was not available
• Have a patient with an identified phenotype, but prefer to test a large number of genes related to the specified clinical indications
• Would like to expand on the fixed content panels currently offered through LifeLabs Genetics or any other provider of genetic testing
• Would like the ability to reflex to a larger data set if their choice in panel comes back negative

These tests do not identify your ancestry.

• Babies, children, and adults can all benefit from genetic testing depending on the health issues or life events they are facing
• Turnaround times vary by test; results may become available to your physician in 4 to 6 weeks; expedited testing for prenatal cases is also available
• Timing estimates do not include time required for physician appointments, requisitions, consent signatures, sample collection, statutory holidays, or courier/shipping times (samples are analyzed in Toronto or Germany)

• Panel testing utilizes next-generation sequencing to achieve optimal coverage of targeted bases
• Fx Panels have >99% technical sensitivity across SNVs
• Ex Panel has >99.6% technical sensitivity
• ProGx Panels have >99.1% technical sensitivity
• Simplified Pricing Structure – Most panels are $1,500 CAD, including CNV analyses

Reports are sent to physicians only; LifeLabs Genetics cannot share results directly with patients. The ordering physician will receive an email or fax when results become available. Actual results are never shared via email.

Results documentation includes the following:

• Test type, date, methodology, result, and interpretation
• Positive result: Indicates a genetic variant was identified in a specific gene and that variant is pathogenic of likely pathogenic (highly likely to be causal of the disease-related condition).
• Uncertain result: Sometimes, gene variants are proven but their significance is not clear. This is stated in the results and discussed with you by your physician. This category of variant is not reported for fetal samples or samples from deceased persons.
• Negative result: If no disease-causing variant is found, genetic changes responsible for the disease or a tendency to have a disease may still exist and cannot usually be fully excluded.