The WES technique is a burgeoning topic in personalized medicine, which puts the focus of care on the precise genetic composition, health, and wishes of the individual rather than applying a category-based treatment regimen. WES is particularly useful for prenatal, neonatal, postnatal, and pediatric patients in determining the negative influences on a child’s overall development but, when diagnoses are not possible, it is also helpful for adults to reveal molecular mechanisms underlying unusual neurological conditions, cardiomyopathies, bone diseases, and metabolic abnormalities, to name a few.