Whole Exome Sequencing

$1,550

Starting at $1550

Includes:

  • Physician-ordered
  • Many specimen types are accepted, including blood, histology samples, tissue, and saliva
  • Available as singleton or trio
  • Reliably covers 97-98% of coding regions at >10x
  • >93% technical sensitivity and >88% technical specificity
  • Deletion/duplication analyses by aCGH and mitochondrial analyses available as add-ons
  • Raw data (.fastq, .bam, or .vcf file formats) and research report available
How to Order

TEST DETAILS

Genetic tests yield a wealth of information – some of it unexpected. Consult with your healthcare provider, speak with your family, and ensure you have access to the latest information before proceeding. The field of genetics is always evolving – and so are we.

TEST FORMS, OPTIONS, AND ORDERING DETAILS

WES is ordered under the guidance of a healthcare provider only. Contact us if you need help or have questions.
Two levels of service are available for this test: gold and platinum:

  • Gold includes 97-98% of targeted bases covered at >10x, with an average read depth of 100x, and an in-depth clinical report.
  • Platinum offers the same sequencing metrics, and also includes prenatal testing and a rapid 3 week turn around time.

For WES, it is mandatory to obtain specific and detailed clinical information. Withholding any clinical or medical information – including family history – may impact test results and their interpretation.

WES/WGS requires a sample from the patient as well as samples from each of the biological parents, whenever possible (trio). Having parental samples can provide genetic insights and improve the results for the patient. With trio cases, reports will not be issued for the parents unless prior arrangements are made.

Test Option

Turn-Around Time

Price  (CDN)

WES Single (Gold)

     8 weeks

$1,950

WES Trio (Gold)

     8 weeks

$3,500

WES Single (Platinum)

     3 weeks

$2, 950

WES Trio (Platinum)

     3 weeks

$6,000

Frequently Asked Questions for the Test

Have a question about genetic testing? Check out our frequently asked questions (FAQs) or contact us.
Does LifeLabs Genetics report variants? Incidental findings?

All disease-causing variants relating to the phenotype reported in HGMD®, ClinVar and CentoMD® (classes 1 and 2), as well as all variants with minor allele frequency of less than 1% in the ExAC database are considered in the medical interpretation. Class 1, 2, and 3 variants are evaluated. Variants that possibly impair the protein sequence are prioritized. All relevant inheritance patterns are considered based on the family history and clinical information submitted with the sample(s). CENTOGENE continuously assesses variants as new information becomes available internally and in the medical literature. When familial studies are recommended, familial variant testing is available for a small fee.

LifeLabs Genetics and CENTOGENE adhere to the “ACMG Recommendations for Reporting of Incidental Findings” and will not report on incidental findings that are not listed in these guidelines. However, it does mean that we will report variants detected in certain genes or classes of genes that are outlined in these recommendations as being medically actionable. Patients who prefer not to receive this information in their report, can opt out of this service. In case of Trio analyses, incidental findings are only analysed for the index patient. Carrier information of the parents for identified incidental findings of the index can be requested with new consent from the parents. Findings will be issued on individual reports. Incidental findings are not reported for fetal samples or samples from deceased persons.

When you purchase a WES package from LifeLabs Genetics, you get sequencing of all exons, end-to-end bioinformatics analysis of raw data, validation or sequencing results, extensive and detailed reports, and access to the raw data. Each WES diagnostic report is validated by CENTOGENE’s team of renowned and experienced clinical specialists and cross-referenced against any family information provided as well as the CentoMD® mutation database. LifeLabs Genetics’ counsellors will also review, interpret, and speak with your physician when unexpected results are found.

Depending on your province of residence, ministry of health coverage could be available. It is always best to first discuss this type of funding with your physician—a referral to a genetics (or other) specialist may be required.

In some provinces, WES test costs are reimbursed only when ordered by a qualified geneticist. This is usually the case in Ontario, for example. Once the geneticist gains approval via a Ministry of Health and Long-Term Care letter, he/she can attach the Ministry’s approval letter to the requisition.

View all frequently asked questions

How to Access to Genetic Testing

Our Customer Care Team is here to support patients and healthcare provider through this process, please contact us.

STEP 1

Learn about<br> LifeLabs Genetics <br>testing

Learn about
LifeLabs Genetics
testing

STEP 2

Choose a test with your healthcare provider

Choose a test with your healthcare provider

STEP 3

Get the appropriate forms online

Get the appropriate forms online

STEP 4

Healthcare provider completes forms

Healthcare provider completes forms

STEP 5

Submit sample, requisition and payment* to LifeLabs

Submit sample, requisition and payment* to LifeLabs

STEP 6

Speak to your healthcare provider about your results

Speak to your healthcare provider about your results

*Most tests have provincial funding coverage; however in some cases payment must be required. The list of required documents, funding criteria and pricing is available on the product specific webpage.

Patient Stories

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Contact Us

Genetic testing can seem complicated. Our team of certified genetic counsellors and client-care specialists are available to support you along the way.

To ensure we provide you with the correct information, please select your province.

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To ensure we provide you with the correct information, please select your province.
  • British Columbia
  • Ontario
  • Alberta
  • Manitoba
  • New Brunswick
  • Newfoundland and Labrador
  • Northwest Territories
  • Nova Scotia
  • Nunavut
  • Prince Edward Island
  • Quebec
  • Saskatchewan
  • Yukon