Since WGS reads and examines practically every piece of DNA in the body and compares it to parental samples whenever possible, WGS reveals both common and rare genetic variants. It flags and interprets changes in the known, active areas and the silent regions of the human genome. WGS facilitates open-ended studies and may be useful in research. But, WGS may also be applied when getting to the root cause directly and quickly is of the utmost priority, when a patient presents with several disorders that obscure diagnoses, or when WES yields less than useful results.