Non-Invasive Prenatal Testing 
Signatera 
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What is Signatera™?
Signatera is a highly sensitive and personalized molecular residual disease (MRD) test using circulating tumor DNA (ctDNA), custom designed for each patient to help quantify tumour burden and identify relapse earlier than standard of care tools.
How Signatera™ helps patients through their treatment
Living scan to scan can sometimes create anxiety for patients.
The question of relapse looms in the back of the mind:
Did the treatment work? Is the cancer coming back?
Through shared decision making, patients can work closely with their care team to incorporate Signatera into their treatment plan to provide additional information for confident decision making.
What does Signatera™ tell me?
Individuals who have already been diagnosed with cancer (solid tumours), and are seeking answers to the following questions:
- Is there cancer left in the body?
- Is additional treatment beneficial?
- Is the treatment working?
Identification and monitoring of solid tissue cancer status by analyzing the associated tumour(s).
Now it is possible detect cancer recurrence earlier than before. Tumour-informed ctDNA testing with Signatera may have clinical utility across cancer types. It helps in the adjuvant setting to detect residual disease early and assess the need for adjuvant chemotherapy personalized to each patient. Signatera can also be used to assess for minimal residual disease more accurately than current risk assessment methods; it may be used alongside CEA to detect recurrence earlier while it may still be resectable, or to reduce false positive CEA results.
Adjuvant setting
- Use Signatera after surgery to evaluate the need for adjuvant chemotherapy
- Personalize and help inform when to reduce treatment
Surveillance setting
- Assess for MRD more accurately than current risk-assessment methods
- Use Signatera alongside CEA to detect recurrence earlier while it may still be resectable, or to reduce false positive CEA results
From the time Natera receives your initial test (i.e. tissue + blood) sample, it may take up to a month for results to become available. For subsequent test (i.e., blood) samples, it may take up to a week.
